President Donald Trump has issued an Executive Order to launch the Genesis Mission, a new national initiative led by the U.S. Department of Energy (DOE). The mission aims to use artificial intelligence (AI) and advanced computing to increase the productivity and impact of American science and engineering over the next decade.
According to the DOE, the Genesis Mission is designed to drive major breakthroughs in energy, scientific discovery, and national security. It will bring together resources from the department’s 17 National Laboratories, industry partners, and academic institutions. The initiative will create an integrated platform connecting supercomputers, AI systems, quantum technologies, and scientific instruments across the country.
“Throughout history, from the Manhattan Project to the Apollo mission, our nation’s brightest minds and industries have answered the call when their nation needed them,” said U.S. Secretary of Energy Chris Wright. “Today, the United States is calling on them once again. Under President Trump’s leadership, the Genesis Mission will unleash the full power of our National Laboratories, supercomputers, and dataresources to ensure that America is the global leader in artificial intelligence and to usher in a new golden era of American discovery.”
The announcement builds on earlier directives such as President Trump’s Executive Order Removing Barriers to American Leadership In Artificial Intelligence and his America’s AI Action Plan released this year. These policies are intended to promote innovation by reducing reliance on foreign technology sources and strengthening domestic research capabilities.
Under Secretary for Science Darío Gil has been appointed as director of the Genesis Mission. He stated: “The Genesis Mission marks a defining moment for the next era of American science. We are linking the nation’s most advanced facilities, data, and computing into one closed-loop system to create a scientific instrument for the ages, an engine for discovery that doubles R&D productivity and solves challenges once thought impossible.”
The DOE expects approximately 40,000 scientists, engineers, technical staff members from its laboratories—along with private sector collaborators—to contribute expertise toward building what it describes as “the world’s most complex and powerful scientific instrument ever built.”
Key focus areas for this mission include:
- Accelerating progress in advanced nuclear technologies, fusion energy development, and grid modernization through AI tools.
- Supporting discovery science by investing in quantum technologies that could support future industries.
- Enhancing national security with advanced AI applications for defense missions—including work related to nuclear stockpile safety.
Brandon Williams, Administrator of the National Nuclear Security Administration (NNSA), commented: “The Genesis Mission represents the next great chapter and an unparallelled opportunity for America’s scientific and national security leadership.
“Building on decades of innovation and collaboration across our national laboratories, NNSA will leverage AI, quantum computing, and advanced data analytics that will strengthen our deterrents and ensure the United States maintains an unmatched strategic edge over our adversaries. Under President Trump’s leadership, this mission will embody the very best of American ingenuity, turning science and innovation into security.”
Dr. John Wagner—Chair of DOE's National Laboratory Directors’ Council—added: “DOE’s National Laboratories are engines of discovery that keep the United States competitive and secure. The Genesis Mission unlocks the full potential of these institutions by giving our scientists and engineers tools to work at the speed of innovation. Our laboratories have always risen to meet the nation’s greatest challenges, and this initiative ensures we continue that legacy in the age of artificial intelligence.”
