The White House has announced the launch of the "Genesis Mission," a new national initiative aimed at accelerating scientific discovery through artificial intelligence (AI). The mission is intended to create an integrated AI platform that will use federal scientific datasets to train advanced models, automate research processes, and drive innovation in key scientific fields.
According to the order issued by President Donald J. Trump, "From the founding of our Republic, scientific discovery and technological innovation have driven American progress and prosperity. Today, America is in a race for global technology dominance in the development of artificial intelligence (AI), an important frontier of scientific discovery and economic growth." The statement draws parallels between this effort and historic projects such as the Manhattan Project.
The Genesis Mission will be led by the Department of Energy (DOE), with oversight from the Secretary of Energy. The Assistant to the President for Science and Technology will provide general leadership and coordinate participating agencies through the National Science and Technology Council.
A central component of this initiative is the creation of the American Science and Security Platform. This infrastructure will offer high-performance computing resources, AI modeling frameworks, computational tools, domain-specific foundation models, secure access to various datasets, and experimental tools for autonomous experimentation and manufacturing.
Within 90 days, DOE must identify available federal computing resources for use in this mission. Within 120 days, initial data assets must be identified along with plans for incorporating additional datasets from other agencies or partners. Further reviews on laboratory capabilities are required within 240 days.
The order also mandates that within 60 days, DOE should identify at least 20 national science and technology challenges that could benefit from AI-driven solutions. These challenges are expected to cover areas such as advanced manufacturing, biotechnology, critical materials, nuclear energy technologies (fission and fusion), quantum information science, semiconductors, and microelectronics.
Coordination among federal agencies is emphasized throughout the order. Participating agencies are directed to align their programs with mission objectives while avoiding duplication. Mechanisms will be established for private-sector collaboration through funding opportunities or prize competitions related to AI-driven research.
Programs for fellowships and internships focused on AI applications in science are also planned. These programs aim to place participants at DOE laboratories or other federal facilities where they can gain experience using AI-enabled research platforms.
Collaboration with external partners possessing advanced capabilities in AI or relevant domains is encouraged under standardized agreements designed to protect intellectual property rights as well as data security standards.
International cooperation may also be considered where appropriate to support activities under this mission.
Annual reporting requirements have been set out: "Within 1 year of the date of this order, and on an annual basis thereafter," DOE must report on operational status; integration across labs; user engagement; measurable advances; public-private partnerships; technology transitions; commercialization activities; as well as any recommendations needed for further progress toward mission objectives.
President Trump concluded: "This order launches the 'Genesis Mission' as a dedicated, coordinated national effort to unleash a new age of AI‑accelerated innovation and discovery that can solve the most challenging problems of this century."
